Figure 4.

Classification in three hematological spectra based on cytological evaluation. (A) Representative pictures of normal density bone marrow defining spectrum 0 (left, objective 10x), hypocellular bone marrow (objective 10x) and an example of myelodysplastic-related changes: multinuclear megakaryocyte (objective 63x) reported in patients in spectrum 1 (middle), blast cells defining overt transformation for spectrum 2 including myelodysplastic syndromes (MDS) with excess of blasts, acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) (objective 63x, right). (B) Proportion of patients in each spectrum (0, 1 and 2), P=not significant. (C) Distribution of patient age in each spectrum. (D) Percentage of patients with missense or null mutations in each spectrum. (E) Blood count parameters (hemoglobin level, platelet, granulocyte, monocyte and lymphocytes counts) of 78 patients in each spectrum. All data points represent each patient values according to spectra with median (wide dots) ± quartiles (small dots). P values are calculated using unpaired t-tests ***P<0.001, **P<0.01, *P<0.05.