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. 2022 Oct 27;108(6):1640–1651. doi: 10.3324/haematol.2021.280424

Figure 3.

Figure 3.

Use of immunomodulatory drugs and/or proteasome inhibitors in first-treatment line of multiple myeloma by country and age group. In 2009 the Danish treatment guidelines changed to recommending bortezomib and dexamethasone (VD) in first line for patients eligible for autologous stem cell transplant (ASCT) and melphalan, prednisolone and thalidomide (MPT) or melphalan, prednisolone and bortezomib (MPV) for those ineligible (marked by the red vertical line). In Sweden, the treatment guidelines changed in 2010 (blue vertical line). Bortezomib and thalidomide were recommended as part of standard induction treatment before ASCT. MPT was recommended as standard for patients not eligible for ASCT, while MPV and melphalan and prednisolone were treatment options.