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. 2023 May 31;113(1):68–82. doi: 10.1007/s00223-023-01100-4

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Fig. 2 — Involvement of senescent BMAds and the SASP in glucocorticoid-induced bone loss. Glucocorticoid treatment induces primary senescence of BMAds through a positive interacting feedback loop of 15d-PGJ2-PPARγ-INK signaling. The senescent BMAds spread senescence to other bone and bone marrow cells, leading to an accumulation of senescent cells for bone impairment