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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2022 Sep 29;76:129013. doi: 10.1016/j.bmcl.2022.129013

Scheme 1.

Scheme 1.

Reagents and conditions: (a) 1-Boc-piperazine (6), DIEA, CH2Cl2, 81%; (b) TFA, CH2Cl2, 97%; (c) Ethyl bromoacetate, K2CO3, DMF, 40 ºC, 92%; (d) LiOH, H2O, THF, 99%; (e) ArNH2, HATU, DIEA, DMF, 4–64%; (f) chloroacetyl chloride, NEt3, DMAP, CH2Cl2; (g) 8, K2CO3, KI, DMF, 50 ºC, 7% (2 steps).