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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2022 Sep 29;76:129013. doi: 10.1016/j.bmcl.2022.129013

Scheme 2.

Scheme 2.

Reagents and conditions: (a) Ethyl bromoacetate, K2CO3, DMF, 68%; (b) LiOH, H2O, THF, 98%; (c) 5-chloro-2-methoxyaniline, HATU, DIEA, DMF, 61%; (d) TFA, CH2Cl2, 100%; (e) R2SO2Cl, DIEA, CH2Cl2; 41–58%; (f) 4-nitrophenyl chloroformate, CH2Cl2, 0 ºC; (g) cyclic secondary amine, NMP, µwave, 200 ºC, 25 min, 32–51% (2 steps).