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Methylated linker 2 analogs
| |||||
|---|---|---|---|---|---|
| No. | * | R | Modea | IC50 / EC50 (µM)b | Efficacy (%)b,c |
| 60 | S | Cl | Inh | 4.4 | 93 |
| 61 | S | CF3 | Inh | 3.4 | 95 |
| 62 | R | Cl | Inh | 4.9 | 98 |
| 63 | R | CF3 | Inh | 3.5 | 100 |
Inh = inhibitor; Act = activator; NA = not active
CRC from Tl+ flux assay in HEK-293 cells expressing WT Slack
Amplitude of response in the presence of 30 µM test compound as a percentage of the maximum response for VU0606170
