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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2022 Sep 29;76:129013. doi: 10.1016/j.bmcl.2022.129013

Table 6.

Comparison of activity versus WT and A934T Slack for select inhibitors

No. WT A934T
IC50 (µM)a Efficacy (%)a,b IC50 (µM)a Efficacy (%)a,b
4 2.4 100 1.4 100
24 4.9 102 2.3 100
27 2.4 89 1.3 88
33 4.3 95 3.1 95
60 4.4 93 2.7 98
61 3.4 95 2.5 96
62 4.9 98 2.9 106
63 3.5 100 2.8 102
71 3.5 93 2.1 94
87 2.4 101 1.1 100
a

CRC from Tl+ flux assay in HEK-293 cells expressing either WT or A934T Slack

b

Amplitude of response in the presence of 30 µM test compound as a percentage of the maximum response for VU0606170