Table 7.
Slo family selective for select Slack inhibitors
| No. | Slick (Slo2.1) | Maxi-K (Slo1 α1/β3) | ||
|---|---|---|---|---|
| IC50 (µM)a | Efficacy (%)a,b | IC50 (µM)a | Efficacy (%)a,b | |
| 4 | >10c | 35 | inactive | |
| 27 | 4.1 | 29 | >10c | 36 |
| 61 | >10c | 34 | inactive | |
| 87 | >10c | 50 | >10c | 32 |
a
CRC from Tl+ flux assay in HEK-293 cells expressing either Slick (Slo2.1) or Maxi-K (Slo1 α1/β3)
b
Amplitude of response in the presence of 30 µM test compound as a percentage of the maximum response for SKF96365 (Slick) or paxilline (Maxi-K)
c
CRC does not plateau within the concentration range tested