Table 1.
Distribution of pfcrt, pfmdr1 and pfatp6 in Plasmodium falciparum isolates from southern Somalia. Data is presented as the number of isolates (%)
| Gene | Codon | Amino Acid | No. of isolates (%) | ||
|---|---|---|---|---|---|
|
| |||||
| Afgoi | Balad | Total | |||
| pfcrt | 76 | K (Wild-type) | 15 (17.4) | 0 (0.0) | 15 (17.4) |
| Tb (Mutation) | 54 (62.8) | 17 (19.8) | 71 (82.6) | ||
| 220 | A (Wild-type) | 2 (2.3) | 0 (0.0) | 2 (2.3) | |
| Sb (Mutation) | 67 (77.9) | 17 (19.8) | 84 (97.7) | ||
| 271 | Q (Wild-type) | 1 (1.2) | 0 (0.0) | 1 (1.2) | |
| Eb (Mutation) | 68 (79.1) | 17 (19.8) | 85 (98.8) | ||
| 326 | N (Wild-type) | 7 (8.1) | 11 (12.8) | 18 (20.9) | |
| Sb (Mutation) | 62 (72.1) | 6 (7.0) | 68 (79.1) | ||
| 356 | I (Wild-type) | 67 (77.9) | 17 (19.8) | 84 (97.7) | |
| Tb (Mutation) | 2 (2.3) | 0 (0.0) | 2 (2.3) | ||
| 371 | R (Wild-type) | 5 (5.8) | 0 (0.0) | 5 (5.8) | |
| Ib (Mutation) | 64 (74.4) | 17 (19.8) | 81 (94.2) | ||
|
| |||||
| pfmdr1 | 86a | N (Wild-type) | 7 (8.2) | 6 (7.1) | 13 (15.3) |
| Yb (Mutation) | 62 (72.9) | 10 (11.8) | 72 (84.7) | ||
| 184 | Y (Wild-type) | 25 (29.4) | 7 (8.2) | 32 (37.6) | |
| Fb (Mutation) | 44 (51.8) | 9 (10.6) | 53 (62.4) | ||
| 1034 | S (Wild-type) | 69 (81.2) | 16 (18.8) | 85 (100.0) | |
| 1042 | N (Wild-type) | 69 (81.2) | 16 (18.8) | 85 (100.0) | |
| 1246 | D (Wild-type) | 69 (81.2) | 16 (18.8) | 85 (100.0) | |
| Copy no. | 1 copy | 65 (77.4) | 16 (19.0) | 81 (96.4) | |
| 2 copies | 3 (3.6) | 0 (0.0) | 3 (3.6) | ||
|
| |||||
| pfatp6 | 37 | R (Wild-type) | 67 (77.9) | 16 (18.6) | 83 (96.5) |
| Kb (Mutation) | 3 (3.5) | 0 (0.0) | 3 (3.5) | ||
| 639 | G (Wild-type) | 66 (76.7) | 16 (18.6) | 82 (95.3) | |
| Db (Mutation) | 4 (4.7) | 0 (0.0) | 4 (4.7) | ||
| 769 | S (Wild-type) | 70 (81.4) | 16 (18.6) | 86 (100.0) | |
| 898 | I (Wild-type) | 46 (53.5) | 11 (12.8) | 57 (66.3) | |
|
| |||||
| Ib (Mutation) | 24 (27.9) | 5 (5.8) | 29 (33.7) | ||
a
Statistically significant difference between Afgoi and Balad isolates (P=0.006).
b
Mutation codons.
pfcr, P. falciparum chloroquine resistance transporter; pfmdr1, P. falciparum multidrug resistance 1; pfatp6, P. falciparum ATPase 6.