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. 2023 May 31;23:491. doi: 10.1186/s12885-023-10934-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Establishment and validation of LMRGs prognostic signature for patients with EC. a Multivariate Cox regression analysis of LMRGs. b, c Risk score distribution and survival status of EC samples based on the risk score. d The PCA, based on all genes, lactate-related genes, and riskgenes, indicate that tumor samples and adjacent tissues are wellseparated by first principal component (PC1) and second principal component (PC2). e, f The Kaplan?Meier survival curves of OS and PFS according to high-and low-risk groups in patients with EC. g, h The univariate Cox regression and multivariate analysis of age, grade, stage, and risk score for OS. i ROC indicated the predictive accuracy of Riskscore was superior to other clinical parameters