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. 2023 May 31;23:53. doi: 10.1186/s40644-023-00557-8

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — 45-year-old female with multifocal grade 2 invasive ER positive HER2 negative metastatic lobular breast cancer: 99m Tc MDP planar bone scan (a, b) and coronal maximum intensity projection PET/CT (c) show no uptake in the axial or appendicular skeleton. Coronal and sagittal CT reformats (d, e) performed 1 week later demonstrating subtle sclerotic changes. Sagittal fat saturated T2W sequence of the spine (f, g) shows heterogenous marrow signal. Fused axial PET/CT (h) shows no FDG avidity. Widespread bone metastases in the same patient on WB DW-MRI (i) axial T1W (j) b900 and (k) ADC