Table 4.
Top 5 significant canonical pathways identified by Ingenuity Pathway Analysis for each comparison in Large White
| Comparison | Ingenuity Canonical Pathways | -log(p-value) | Overlap ratio (%) | Z-score |
|---|---|---|---|---|
| RF vs. NF. after P2 | Protein Ubiquitination Pathway | 2.82 | 2.55 | |
| Unfolded protein response | 2.65 | 4.44 | ||
| Aldosterone Signaling in Epithelial Cells | 2.48 | 3.05 | ||
| Sirtuin Signaling Pathway | 2.05 | 2.05 | -2 | |
| SNARE Signaling Pathway | 2.02 | 2.94 | 0 | |
| RF vs. NF. after P3 | Oxidative Phosphorylation | 3.44 | 7.21 | 1.414 |
| HIF1α Signaling | 3.34 | 5.29 | 0.302 | |
| Apelin Adipocyte Signaling Pathway | 2.51 | 6.59 | -0.816 | |
| HER-2 Signaling in Breast Cancer | 2.5 | 4.41 | -1.414 | |
| Mitochondrial Dysfunction | 2.25 | 4.68 | ||
| P3 vs. P2. NF | Superpathway of Citrulline Metabolism | 3.96 | 33.3 | -0.447 |
| Citrulline Biosynthesis | 3.81 | 44.4 | 0 | |
| Sirtuin Signaling Pathway | 3.64 | 7.88 | 0.5 | |
| EIF2 Signaling | 3.51 | 8.48 | -1.387 | |
| Primary Immunodeficiency Signaling | 3.19 | 14.3 | ||
| P3 vs. P2. RF | Protein Ubiquitination Pathway | 5.55 | 14.2 | |
| Sirtuin Signaling Pathway | 4.92 | 13.4 | -0.192 | |
| Huntington’s Disease Signaling | 4.15 | 12.7 | -1.414 | |
| Inhibition of ARE-Mediated mRNA Degradation Pathway | 4 | 14.9 | 0.471 | |
| cAMP-mediated signaling | 3.59 | 12.8 | 0.784 |
NF : Normal Feeding
RF : Restricted Feeding
P2 : Period 2 (end of restriction)
P3 : Period 3 (end of refeeding)