Table 5.
Top 5 significant canonical pathways identified by Ingenuity Pathway Analysis for each comparison in Creole
| Comparison | Ingenuity Canonical Pathways | -log(p-value) | Overlap ratio (%) | Z-score |
|---|---|---|---|---|
| RF vs. NF. after P2 | Interferon Signaling | 7.34 | 25 | -3 |
| Pancreatic Adenocarcinoma Signaling | 4.8 | 9.52 | -0.632 | |
| Ephrin Receptor Signaling | 4.51 | 7.39 | -2.309 | |
| RAC Signaling | 4.4 | 8.7 | -1.265 | |
| Th1 Pathway | 4.23 | 9.02 | -1.667 | |
| RF vs. NF. after P3 | Citrulline Biosynthesis | 2.91 | 22.2 | |
| Antigen Presentation Pathway | 2.8 | 7.69 | ||
| Superpathway of Citrulline Metabolism | 2.46 | 13.3 | ||
| Sirtuin Signaling Pathway | 2.1 | 2.05 | -0.447 | |
| Role of PKR in Interferon Induction and Antiviral Response | 2.06 | 2.94 | 0 | |
| P3 vs. P2. NF | Interferon Signaling | 5.5 | 19.4 | -1.89 |
| Gαs Signaling | 3.34 | 7.2 | 0 | |
| Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza | 3.03 | 8.14 | -1.134 | |
| Myo-inositol Biosynthesis | 2.5 | 40 | ||
| cAMP-mediated signaling | 2.42 | 4.68 | 0.302 | |
| P3 vs. P2. RF | Protein Ubiquitination Pathway | 5.4 | 10.5 | |
| Sirtuin Signaling Pathway | 5.34 | 10.3 | -0.229 | |
| Virus Entry via Endocytic Pathways | 3.45 | 12.5 | ||
| Role of BRCA1 in DNA Damage Response | 3.36 | 13.8 | 0 | |
| Aldosterone Signaling in Epithelial Cells | 3.34 | 10.4 | -0.707 |
NF : Normal Feeding
RF : Restricted Feeding
P2 : Period 2 (end of restriction)
P3 : Period 3 (end of refeeding)