Table 1.
Demographic and clinical characteristics of the cohorts being used as our historical controls for this study
| Cohort characteristic | Control cohort for ICU phase*38 | Control cohort #1 for recovery phase† 21 | Control cohort #2 for recovery phase39 |
| ICU or admission type | Medical 73%; cardiothoracic 27% | Medical 100% | Mixed |
| Years of enrolment | 2018–2019 | 2018–2019 | 2018–2021 |
| N | 41* | 12† | 59 |
| Primary inclusion | Acute respiratory failure or sepsis and anticipated ICU stay >3 days | Survivors of acute respiratory failure requiring >48 hours of mechanical ventilation | Survivors of sepsis and/or acute respiratory failure |
| Timing of initial assessment | Within 48 hours of admission; median 1.1 days (IQR 0.7–1.4) | N/A | N/A |
| Timing of outpatient assessment | N/A | 4–8 weeks after hospital discharge | 3 months after hospital discharge |
| Age, median years (IQR) | 61 (55–68) | 58 (45.5–65) | 56 (48–64) |
| Female, no (%) | 18 (44) | 4 (33) | 31 (53) |
| No (%) mechanically ventilated | 30 (73) | 12 (100) | 43 (73) |
| Duration of mechanical ventilation, median days (IQR) | 3.4 (1–7.7) | 6.45 (2.8–11.95) | 8 (5–14) |
| No (%) requiring RRT | 5 (12)* | NR† | 0 |
| Disease severity (SOFA) scores | Mean 8.1 (SD±4.8) | Median 8 (IQR 4.5–10.25) | Median 10 (IQR 8–12) |
| ICU LOS, median days (IQR) | 8 (4) | 7.4 (4.3–18.6) | 10 (6–15) |
| Hospital LOS, median days (IQR) | 11.2 (8–19) | 16.7 (9.4–28.7) | 15 (11–22) |
| Hospital mortality | 12% | N/A | N/A |
Presented here are only previously published data. The two control cohorts for the recovery phase represented in the table are only a subset of the 200 patients in our ongoing registry that will serve as the control for the recovery phase.
*Data for this entire cohort are presented as published, including data from the five patients treated with RRT who will be excluded from the control group in our analysis.
†Though not reported in the published manuscript, RRT status is available for this cohort and any patients with AKI-RRT will be excluded from the control group in our analysis.
AKI, acute kidney injury; ICU, intensive care unit; LOS, length of stay; N/A, not applicable; NR, not reported; RRT, renal replacement therapy; SOFA, Sequential Organ Failure Assessment.