Table 2.

Planned evaluations at each study time point

Parameter	Time point
	ICU phase			Recovery phase
	Within 48 hours of CRRT start	3±1 days from enrolment	Study day 7 (or ICU discharge)	Hospital discharge	Outpatient 1–3 months
Rectus femoris US	X	X	X	X	X
Amino acids (blood)	X	X	X
Amino acids (Effluent)	X	X	X
Cystatin C	X	X	X
ICU Mobility Scale	X	X	X
Muscle Strength—MRC-ss				X	X
Muscle strength—HGD				X	X
Muscle Strength—HHD				X	X
SPPB				X	X
TUG test					X
6-MWT					X
EQ-5D-5L					X
Clinical Frailty Scale					X
FACIT-fatigue					X
SF-36 Physical Function					X
Return to driving					X
Return to work or hobby					X
Readmission					X
ED visit					X

ED, emergency department; EQ-5D-5L, EuroQol Group 5-dimension 5-level version; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; HGD, hand-grip dynamometry; HHD, hand-held dynamometry; ICU, intensive care unit; MRC-ss, Medical Research Council sum-score; 6-MWT, six min walk test; SF-36, 36-Item Short Form Health Survey; SPPB, Short Physical Performance Battery; TUG, Timed Up and Go; US, ultrasound.