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. 2023 May 22;11(5):e006649. doi: 10.1136/jitc-2022-006649

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Expression of IL-15 inversely correlates with MYC expression in human B-cell malignancies. (A)Comparison of peripheral blood cDC frequencies within the HLA-DR⁺ non-B, non-T, and non-NK immune cell fraction of B-ALL patients (n=10) and healthy donors (n=10) by flow cytometry. (B)Linear regression analyzing the correlation between MYC and IL-15 transcript expression and plots of MYC and IL-15 mRNA expression in B-ALL patients with three major subtypes of leukemia from three independent data sets: EGAS00001003266 (ETV6::RUNX1 (n=187); ETV6::RUNX1-like (n=42); Ph/Ph-like (n=482), MYC-BCL2-driven /KMT2A-rearranged /Hypodiploid (n=237); 672 children and 240 adults, 36 unknown), the COG P9906 GSE11877 (ETV6::RUNX1 (n=3); others including Ph-like (n=155); KMT2A-rearranged (n=21); all pediatric) and in MILE GSE13159 (MYC driven+MLL (n=83); ETV6::RUNX1 (n=94); Ph⁺ (n=122)) data sets. (C)Comparison of transcript levels of MYC and IL-15 in classical MYC-driven Burkitt’s lymphoma/leukemia and non-MYC-driven B-cell lymphoma types from GSE132929: (Burkitt’s lymphoma (n=59) and non-Burkitt’s lymphoma (n=231). Non-MYC-driven (non-Burkitt’s) lymphomas include diffuse large B-cell lymphoma (n=95), follicular lymphoma (n=65), unspecified high-grade B-cell lymphoma (n=4), mantle cell lymphoma (n=43), double hit lymphoma (n=1), and marginal zone lymphoma (n=23)). B-ALL, B-cell acute lymphoblastic leukemia; cDC, conventional dendritic cell; NK, natural killer.