FIG 7.

Early accumulation of ZIKV proteins impacts the host innate immune response and control of viral replication and spread; model figure demonstrating how early accumulation of viral proteins impacts the host innate immune response to ZIKV/Dakar (left) and ZIKV/Malaysia (right) infections. Early accumulation of ZIKV/Malaysia proteins confers enhanced ability to block IFN-β signaling and ISG induction compared to ZIKV/Dakar. Activation of RIG-I-mediated antiviral signaling restricts ZIKV/Dakar protein accumulation, thereby limiting viral genome accumulation and spread.