TABLE 1.
All amino acid differences between ZIKV/Dakar and an Asian lineage reference straina
| Position | Substitution | Type of substitution | Protein |
|---|---|---|---|
| 7 | K to N | Nonconservative | Capsid |
| 25 | S to N | Conservative | Capsid |
| 27 | F to L | Conservative | Capsid |
| 101 | K to R | Conservative | Capsid |
| 110 | V to I | Conservative | Capsid |
| 123 | V to A | Conservative | prb |
| 125 | V to I | Conservative | pr |
| 148 | P to A | Conservative | pr |
| 157 | Y to H | Nonconservative | pr |
| 158 | I to V | Conservative | pr |
| 246 | R to K | Conservative | Mb |
| 260 | A to L | Conservative | M |
| 262 | A to V | Conservative | M |
| 575 | S to F | Nonconservative | Eb |
| 607 | I to V | Conservative | E |
| 727 | A to V | Conservative | E |
| 728 | L to F | Conservative | E |
| 785 | L to M | Conservative | E |
| 846 | D to E | Conservative | NS1 |
| 863 | R to K | Conservative | NS1 |
| 926 | S to R | Nonconservative | NS1 |
| 956 | V to I | Conservative | NS1 |
| 982 | A to V | Conservative | NS1 |
| 988 | V to A | Conservative | NS1 |
| 1007 | K to R | Conservative | NS1 |
| 1030 | I to V | Conservative | NS1 |
| 1180 | I to M | Conservative | NS2A |
| 1191 | I to V | Conservative | NS2A |
| 1204 | A to V | Conservative | NS2A |
| 1226 | I to V | Conservative | NS2A |
| 1263 | V to A | Conservative | NS2A |
| 1270 | D to E | Conservative | NS2A |
| 1275 | I to V | Conservative | NS2A |
| 1297 | T to A | Nonconservative | NS2A |
| 1354 | L to I | Conservative | NS2A |
| 1461 | D to E | Conservative | NS2B |
| 1477 | T to A | Nonconservative | NS2B |
| 1553 | H to Q | Nonconservative | NS3 |
| 1558 | S to A | Nonconservative | NS3 |
| 1594 | H to L | Nonconservative | NS3 |
| 1620 | T to K | Nonconservative | NS3 |
| 1671 | R to K | Conservative | NS3 |
| 1676 | T to A | Conservative | NS3 |
| 1687 | K to R | Conservative | NS3 |
| 1717 | T to K | Nonconservative | NS3 |
| 1862 | V to I | Conservative | NS3 |
| 1909 | V to I | Conservative | NS3 |
| 1962 | I to V | Conservative | NS3 |
| 2085 | R to K | Conservative | NS3 |
| 2123 | F to L | Conservative | NS4A |
| 2127 | E to D | Conservative | NS4A |
| 2282 | L to I | Conservative | NS4B |
| 2283 | G to A | Conservative | NS4B |
| 2289 | R to K | Conservative | NS4B |
| 2293 | A to T | Nonconservative | NS4B |
| 2594 | Y to H | Nonconservative | NS5 |
| 2598 | I to V | Conservative | NS5 |
| 2621 | K to R | Conservative | NS5 |
| 2634 | T to M | Nonconservative | NS5 |
| 2659 | S to P | Nonconservative | NS5 |
| 2679 | A to T | Nonconservative | NS5 |
| 2715 | L to M | Conservative | NS5 |
| 2722 | Y to H | Nonconservative | NS5 |
| 2765 | D to E | Conservative | NS5 |
| 2795 | L to M | Conservative | NS5 |
| 2800 | N to R | Nonconservative | NS5 |
| 2802 | V to I | Conservative | NS5 |
| 2807 | S to N | Conservative | NS5 |
| 2842 | I to V | Conservative | NS5 |
| 2909 | H to R | Conservative | NS5 |
| 2969 | Q to H | Nonconservative | NS5 |
| 3039 | V to I | Conservative | NS5 |
| 3044 | S to N | Conservative | NS5 |
| 3046 | T to A | Nonconservative | NS5 |
| 3154 | Q to H | Nonconservative | NS5 |
| 3161 | R to K | Conservative | NS5 |
| 3167 | S to R | Nonconservative | NS5 |
| 3239 | Y to H | Nonconservative | NS5 |
| 3257 | I to F | Conservative | NS5 |
| 3304 | S to A | Nonconservative | NS5 |
| 3307 | V to I | Conservative | NS5 |
| 3333 | V to M | Conservative | NS5 |
| 3335 | W to C | Conservative | NS5 |
| 3402 | Y to F | Nonconservative | NS5 |
a
Column 1 indicates the position of amino acid residue relative to the polyprotein. Column 3 shows whether the amino acid substitution retains (conservative) or changes (nonconservative) the biochemical properties of the original amino acid residue.
b
pr, peptide; M, membrane; E, envelope.