Fig. 3. Overlay at the C-SH2 domain (colored in orange) of the autoinhibited structure of SHP2 and of the representative structures of the clusters 1 and 3–8, which did not exhibit significant spatial clashes between N-SH2 (cyan) and PTP (pink). The N-SH2 domain in the autoinhibited structure is shown as transparent ribbon. The catalytic loop of PTP is indicated in red.