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. 2023 May 27;16:2271–2296. doi: 10.2147/JIR.S406298

Figure 1.

Figure 1

Continued.

Figure 1.

Figure 1

The effects of Mag on severity of arthritis in CIA mice. (A) Joint swelling of mice in each group. (B) Arthritis scores of mice in each group (n = 15). D37, ##p<0.01, Model+Mag-M vs Model group; &&p<0.01 Model+Mag-H vs Model group; D41, $$p<0.01, Model+MTX vs Model group; *p<0.05, Model+Mag-L vs Model group; ###p<0.001, Model+Mag-M vs Model group; &&&p<0.001, Model+Mag-H vs Model group; D45, $p<0.05, Model+MTX vs Model group; ###p<0.001, Model+Mag-M vs Model group; &&&p<0.001, Model+Mag-H vs Model group; D49, $$$p<0.001, Model+MTX vs Model group; **p<0.01, Model+Mag-L vs Model group; ###p<0.001, Model+Mag-M vs Model group; &&&p<0.001, Model+Mag-H vs Model group. (C) Representative Micro-CT 3-D reconstructed images of ankle joints in mice (n = 15). The articular damage was indicated by the red arrows. Control group, normal mice; Model group, CIA mice models; Model+MTX group, methotrexate-treated mice (1mg/kg/d)+CIA; Model+Mag-L group, mice with magnoflorine treatment (5mg/kg/d)+CIA; Model+Mag-M group, mice with magnoflorine treatment (10mg/kg/d)+CIA; Model+Mag-H group, mice with magnoflorine treatment (20mg/kg/d)+CIA.

Abbreviations: CIA, collagen induced arthritis; Mag, magnoflorine; Micro-CT, micro-computed tomography.