Figure 2.

Continued.

Figure 2.

The effects of Mag on the histopathological changes in ankle joints and spleens in CIA mice. (A) Representative photomicrographs of HE-stained histological sections (magnification, ×100) of the ankle joints are shown. The histology sections of the ankle joints include the synovial hyperplasia (yellow arrow), pannus formation (green arrow), and infiltration of inflammatory cells (blue arrow), as well as bone erosion (black arrow). (B) Histopathological scores of ankle joints in each group (n = 15). (C) Representative photomicrographs of HE-stained histological sections (magnification, ×100) of the spleen are shown. The histology section of the spleen include the germinal center (green arrow), red pulp (yellow arrow), and marginal zone (black arrow). (D) Histopathological scores of spleens in each group (n = 15). *p<0.05, **p<0.01, ***p<0.001 (one-way ANOVA with Tukey’s post hoc test).

Abbreviations: CIA, collagen induced arthritis; HE, hematoxylin-eosin; Mag, magnoflorine.