TABLE IV.
Outcomes in Therapy Non-responders, n = 11 (12-month Post-operative AHI ≥5).
| Characteristic | Baseline (SD) | 12-Month (SD) | Change (SD) | P Value |
|---|---|---|---|---|
|
| ||||
| Parent-reported outcomes | ||||
| OSA-18 | ||||
| Survey score | 3.5 (1.1) | 1.8 (0.9) | −1.7 (1.4) | .002 |
| Total score | 70.7 (13.4) | 31.5 (9.5) | −38.5 (20.1) | .005 |
| Domain average scores | ||||
| Sleep disorders | 4.6 (1.4) | 2.1 (0.9) | −2.5 (1.4) | .0003 |
| Physical distress | 2.1 (0.9) | 1.9 (0.8) | −0.2 (0.8) | .46 |
| Emotional distress | 3.2 (1.8) | 1.8 (1.0) | −1.2 (1.9) | .07 |
| Diurnal problems | 3.6 (1.1) | 2.3 (1.0) | −1.3 (1.4) | .02 |
| Caretaker | 4.2 (1.7) | 1.6 (0.8) | −2.6 (2.0) | .003 |
| Preoccupation | ||||
| Overall quality of Life* | 4.1 (1.8) | 7.7 (1.6) | +3.5 (1.7) | .0001 |
| Epworth sleepiness score mean score | 7.6 (5.4) | 5.0 (5.2) | −2.1 (3.3) | .07 |
| Polysomnographic outcomes | ||||
| Respiratory events | ||||
| AHI | 22.1 (9.2) | 13.8 (16.0) | −8.2 (12.4) | .05 |
| Obstructive AHI | 19.9 (8.9) | 12.4 (15.2) | −7.5 (12.1) | .07 |
| Central apnea index | 2.2 (1.5) | 1.5 (1.5) | −0.65 (2.1) | .32 |
| Hypopnea proportion | 70.7% (25.3%) | 80.9% (15.0%) | 10.2% (28.9%) | .27 |
| Supine AHI | 23.4 (15.5) | 17.8 (18.6) | −5.6 (14.1) | .22 |
| Oxygenation | ||||
| Percentage of time | 5.5% (12.2%) | 0.84% (2.8%) | −4.7% (12.8%) | .11 |
| SpO2 < 90% | ||||
| SpO2 Nadir | 85.2% (6.1%) | 87.6% (5.2%) | +2.4% (5.3%) | .05 |
| Baseline SpO2 | 96.4% (1.5%) | 95.0% (1.5%) | −1.3% (1.5%) | .01 |
| Sleep fragmentation | ||||
| Sleep efficiency | 67.3% (16.2%) | 69.2% (19.9%) | +1.9% (23.7%) | .80 |
| Stage N1 percentage | 7.8% (8.7%) | 4.6% (5.0%) | −3.2% (7.4%) | .07 |
| REM percentage | 13.6% (8.0%) | 12.6% (0.1%) | −1.0% (10.3%) | .75 |
AHI = apnea-hypopnea index; SD = standard deviation; REM = rapid eye movement; SpO2 = oxygen saturation.
*
Scored on a scale of 0 to 10 where higher scores correspond to better quality of life.