Table 1.
Comparison of Baseline Characteristics in Children With Respiratory Tract Infection and Detection of HBoV1 DNA, HBoV1-mRNA and RSV
| HBoV1-DNA (n = 274) | HBoV1-mRNA+ vs. mRNA- | RSV (n = 1447)a | HBoV1-mRNA+ vs. RSV | ||
|---|---|---|---|---|---|
| mRNA+ (n = 130)a | mRNA- (n = 144) | OR (95% CI) | OR (95% CI) | ||
| Age, median (interquartile range), months | 15.3 (12.1–19.6) | 18.3 (13.2–26.9)b | 7.9 (2.6–18.9)b | ||
| Age group (months) | |||||
| <6 | 7 (5.4) | 4 (2.8) | Ref. | 614 (42.4) | Ref. |
| 6–11 | 24 (18.5) | 23 (16.0) | 0.60 (0.1–2.3) | 251 (17.3) | 8.4 (3.6–19.7) |
| 12–17 | 56 (43.1) | 42 (29.2) | 0.76 (0.21–2.8) | 196 (13.5) | 25.1 (11.2–55.9) |
| 18–23 | 23 (17.7) | 31 (21.5) | 0.42 (0.11–1.6) | 161 (11.1) | 12.5 (5.3–29.7) |
| 24–59 | 20 (15.4) | 43 (29.9) | 0.27 (0.07–1.0) | 206 (14.2) | 8.5 (0.94–2.0) |
| ≥60 | 0 (0.0) | 1 (0.7) | — | 19 (1.3) | — |
| Male sex | 85 (65.4) | 87 (60.4) | 1.2 (0.76–2.0) | 838 (57.9) | 1.37 (0.94–2.0) |
| Premature birth (gestational age <36 weeks) | 16/120 (13.3) | 26/132 (19.7) | 0.63 (0.32–1.2) | 188/1427 (13.2) | 1.0 (0.59–1.8) |
| ≥1 chronic diseasec | 33 (25.4) | 43 (29.9) | 0.8 (0.47-1.4) | 247 (17.1) | 1.7 (1.1-2.5) |
The data represents the no. (%) of children unless otherwise specified. Strength of associations estimated by Pearson χ2 test and binary logistic regression as appropriate, and given as OR and 95% CI. CI, confidence interval; HBoV1, human bocavirus 1; OR, odds ratio; RSV, respiratory syncytial virus.
aTwenty children with both HBoV1-mRNA and RSV were included in the HBoV1-mRNA group only.
b p < .001 by Mann–Whitney U test.
cHeart disease, neurologic disease, and/or pulmonary disease.