Table 3.
Frequency of Selected Symptoms Reported During the Examination Visit for Nonstudy Physician’s Diagnosis of LRTI, Bronchiolitis, or Pneumonia, WHO 2015 RSV-LRTI and WHO 2015 Severe RSV-LRTI Cases Occurring in 2401 Children Followed Up for 2 Years From Birth
| Physician’s Diagnosis of LRTI, Bronchiolitis, or Pneumonia (N = 243) | WHO 2015 RSV-LRTI (N = 226) |
WHO 2015 Severe RSV-LRTI (N = 73) |
||||
|---|---|---|---|---|---|---|
| Symptom | n | % (95% CI) | n | % (95% CI) | n | % (95% CI) |
| Cougha | 243 | 100 (98.5–100) | 226 | 100 (98.4–100) | 73 | 100 (95.1–100) |
| Blocked nosea | 214 | 88.1 (83.3–91.9) | 199 | 88.1 (83.1–92.0) | 62 | 84.9 (74.6–92.2) |
| Runny nosea | 224 | 92.2 (88.1–95.2) | 211 | 93.4 (89.3–96.2) | 68 | 93.2 (84.7–97.7) |
| Wheezing | 187 | 77.0 (71.1–82.1) | 182 | 80.5 (74.8–85.5) | 63 | 86.3 (76.2–93.2) |
| Stridor | 21 | 8.6 (5.4–12.9) | 19 | 8.4 (5.1–12.8) | 9 | 12.3 (5.8–22.1) |
| Flare of the nostrils | 24 | 9.9 (6.4–14.3) | 22 | 9.7 (6.2–14.4) | 16 | 21.9 (13.1–33.1) |
| Irritability/agitation | 72 | 29.6 (24.0–35.8) | 66 | 29.2 (23.4–35.6) | 30 | 41.1 (29.7–53.2) |
| Lethargy/sleepiness | 17 | 7.0 (4.1–11.0) | 14 | 6.2 (3.4–10.2) | 8 | 11.0 (4.9–20.5) |
| Any chest indrawing | 56 | 23.0 (17.9–28.9) | 57 | 25.2 (19.7–31.4) | 57 | 78.1 (66.9–86.9) |
| Reduced/no vocalization | 42 | 17.3 (12.7–22.6) | 45 | 19.9 (14.9–25.7) | 18 | 24.7 (15.3–36.1) |
| Any apneaa | 3 | 1.2 (0.3–3.6) | 7 | 3.1 (1.3–6.3) | 4 | 5.5 (1.5–13.4) |
| Cyanosisa | 3 | 1.2 (0.3–3.6) | 2 | 0.9 (0.1–3.2) | 1 | 1.4 (0.0–7.4) |
| Stop feeding well | 68 | 28.0 (22.4–34.1) | 68 | 30.1 (24.2–36.5) | 27 | 37.0 (26.0–49.1) |
| Dehydration | 7 | 2.9 (1.2–5.8) | 5 | 2.2 (0.7–5.1) | 3 | 4.1 (0.9–11.5) |
| Fever (temperature >37.5°C) | 62 | 25.5 (20.2–31.5) | 63 | 27.9 (22.1–34.2) | 24 | 32.9 (22.3–44.9) |
| Vomitinga | 93 | 38.3 (32.1–44.7) | 84 | 37.2 (30.9–43.8) | 32 | 43.8 (32.2–55.9) |
| Diarrheaa | 68 | 28.0 (22.4–34.1) | 71 | 31.4 (25.4–37.9) | 28 | 38.4 (27.2–50.5) |
Abbreviations: CI, confidence interval; LRTI, lower respiratory tract infection; n (%), number (percentage) of cases with each symptom; N, total number of cases according to each definition; RSV, respiratory syncytial virus; WHO, World Health Organization.
Notes:
aSymptoms reported during the interview or on the diary card were also included. All suspected LRTI cases (new or worsened) were included in this analysis.