Visit	MMSE-ADAS-Cog total change scores				MMSE-SIB total change scores
Week	N	MMSE	ADAS-Cog	r	N	MMSE	SIB	r
Week 1	149	0.69 (2.34)	−0.92 (3.68)	−0.11
Week 3	594	0.76 (2.61)	−2.04 (4.31)	−0.28
Week 6	991	0.74 (2.82)	−1.64 (4.65)	−0.28	1225	0.52 (2.35)	2.05 (7.07)	0.31
Week 9	560	0.98 (3.05)	−1.57 (4.70)	−0.32
Week 12	957	0.76 (3.05)	−1.17 (5.11)	−0.36	1156	0.76 (2.76)	2.36 (7.72)	0.37
Week 18	380	0.06 (3.16)	−0.36 (5.31)	−0.39	1095	0.71 (2.94)	2.47 (8.74)	0.43
Week 24	379	−0.31 (3.35)	0.03 (5.76)	−0.45	1548	0.53 (3.08)	1.02 (10.42)	0.44

All r values were statistically significant (p<0.05), except the correlation at week 1 between the MMSE and ADAS-Cog where p=0.18. Spearman’s correlation coefficient values may be interpreted as weak (0.10–0.39), moderate (0.40–0.69) and strong (0.70–0.89).

ADAS-Cog, Alzheimer’s Disease Assessment Scale–Cognitive Subscale; MMSE, Mini-Mental State Examination; N, the sample size that varies owing to different visit schedules across trials; r, Spearman’s correlation coefficient; SIB, Severe Impairment Battery.