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. Author manuscript; available in PMC: 2023 May 31.
Published in final edited form as: Mol Psychiatry. 2022 Sep 20;27(11):4642–4652. doi: 10.1038/s41380-022-01736-y

Fig. 1. Spironolactone decreased binge-like alcohol drinking in mice.

Fig. 1

A Spironolactone dose-dependently reduced alcohol intake (g/kg of body weight) in mice drinking a sweetened alcohol solution [20% alcohol (v/v), 3% glucose (w/v), and 0.1% saccharin (w/v)], and female mice drank significantly more alcohol than male mice. Males: n = 8; Females: n = 7. B Spironolactone dose-dependently reduced alcohol intake (g/kg of body weight) in mice drinking an unsweetened alcohol solution [20% (v/v)]. Males: n = 8; Females: n = 7. C Spironolactone had no effect on the intake (mL/kg of body weight) of a sweet solution without alcohol [0.3% glucose (w/v) and 0.01% saccharin (w/v)] in mice. Males: n = 8; Females: n = 7. Separate cohorts of mice were used for each drinking solution. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, vs. vehicle; #p < 0.05, male vs. female. DID drinking-in−the-dark.