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. Author manuscript; available in PMC: 2023 May 31.
Published in final edited form as: Mol Psychiatry. 2022 Sep 20;27(11):4642–4652. doi: 10.1038/s41380-022-01736-y

Fig. 2. Spironolactone did not affect motor coordination or spontaneous locomotion in mice.

Fig. 2

A Spironolactone treatment had no effect on motor coordination in mice that received a saline injection and were tested 30 min and 90 min later, on the rotarod. Males: n = 6; Females: n = 5. B Systemic administration of alcohol (1.5 g/kg) significantly impaired motor coordination in mice. Males: n = 6; Females: n = 5. Spironolactone treatment had no effect on alcohol-induced ataxia on the rotarod test at any time point. ####p < 0.0001, vs. Baseline. C Spironolactone had no effect on blood alcohol levels 30 min and 90 min after systemic administration of alcohol (1.5 g/kg). ####p < 0.0001, 30 min vs. 90 min. Males: n = 6; Females: n = 5. D Spironolactone had no effect on spontaneous locomotion in the circular corridor. Males: n = 8; Females: n = 6.