Skip to main content
. Author manuscript; available in PMC: 2023 May 31.
Published in final edited form as: Cell Metab. 2023 Mar 23;35(4):695–710.e6. doi: 10.1016/j.cmet.2023.03.001

Figure 4: The T2DKP emphasizes genetic datasets for T2D and related traits.

Figure 4:

We compared genetic datasets for glycemic traits (T2D, fasting glucose, fasting insulin, and HbA1C) in the T2DKP (blue) to those in the GWAS Catalog (orange), the GWAS Atlas (white), and the OpenGWAS project (gray), in October 2022 (Table S2). We conducted an analysis of all datasets and an analysis of datasets newer than 2015 and with >10K samples. a. Considering all datasets in each resource, including those without full summary statistics available, the GWAS Catalog contains the most glycemic trait genetic datasets. b. When only datasets with full summary statistics are considered, the T2DKP contains the most glycemic trait genetic datasets. c. Both the T2DKP and the GWAS Catalog contain datasets unavailable through other resources. d. When only genetic datasets with full summary statistics are considered, the T2DKP contains many more datasets unavailable through other resources. e. Most of the datasets unique to the GWAS Catalog are either from prior to 2015 or contain fewer than 10K samples. f. The T2DKP contains nearly all datasets newer than 2015 and with more than 10K samples. g. Datasets in the T2DKP are predominantly from analyses of European samples, but the ethnic diversity it captures has increased over time.