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. Author manuscript; available in PMC: 2023 May 31.
Published in final edited form as: Cell Metab. 2023 Mar 23;35(4):695–710.e6. doi: 10.1016/j.cmet.2023.03.001

Figure 6: We recommend non-geneticists follow a “genetic support” workflow within the T2DKP.

Figure 6:

To evaluate whether human genetic associations support the involvement of a gene of interest in human disease, users can first use the “region page” to see if the gene lies nearby associations (1), then use the “gene page” to view a distillation of these associations into a gene-level score (2) and also view complementary rare variant associations for the gene (3). The HuGE calculator, also on the gene page, summarizes these two gene-level associations into a single score for the gene (4). The T2DKP effector gene list contains a curated set of genes suggested from genome-wide analyses to be involved in disease (5). Table S4 contains information on these and other modules of the T2DKP.