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. 2023 Jun 1;133(11):e169653. doi: 10.1172/JCI169653

Figure 7. Single-cell CNA and point mutation during thyroid cancer cell progression.

Figure 7

(A and B) Heatmaps of relative copy number ratios of PTC (A) and ATC (B) tumor cells inferred by CopyKAT. (C) Frequency plot of CNAs across patients with mATC. (D) N-J tree of single tumor cells with inferred single-cell copy number data. (E) M-P tree of tumors cells, rooted to an artificial normal TFC. P values were estimated from 1,000 iterations of bootstrap resampling. (F) Paneled single nucleotide variants (SNVs) and aneuploidy of epithelial cell clusters for all patients. Mut, mutation.