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. 2023 Jun 1;133(11):e163968. doi: 10.1172/JCI163968

Figure 2. Tet2 loss-of-function–driven CH exacerbates hyperglycemia and splenomegaly in obese mice.

Figure 2

(A) Schematic demonstrating the generation of Tet2–/– Ob/Ob compound mutant mice along with Tet2–/–, Ob/Ob, and WT control mice. (B–F) Elevated body weights, fasting blood glucose levels, spleen weights, and heart weights were observed in Tet2–/– Ob/Ob compound mutant mice compared with mice in the other groups. (G) Histological analysis of H&E-stained sections of spleen and liver from a representative Tet2–/– Ob/Ob mouse along with controls (n = 5–6 mice per group). Scale bars: 50 μm. Data are shown as the mean ± SEM. *P < 0.05, **P < 0.005, ***P < 0.0005, and ****P < 0.0001, by 1-way ANOVA.