Table 2.
The effect of PRP and PIH on animal weight, serum glucose, and insulin concentration.
| Parameter/group | Con | D | IT | IT-PRP | IT- PIH | IT- PRP&PIH |
|---|---|---|---|---|---|---|
| Average initial weight (g) | 257.7 ± 1.43 | 260.75 ± 1.8 | 258.3 ± 3.11 | 262.23 ± 2.13 | 256.51 ± 2.61 | 258.83 ± 2.78 |
| Average final weight (g) | 359.13 ± 2.55 g4 |
235.99 ± 2.3 a4g2 |
295.41 ± 5.41 a2g3 |
320.81 ± 3.42 a1b2c1g4 |
300.71 ± 5.48 a2g3 |
344.35 ± 4.21 b3c2e1g4 |
| Percentage of weight gain (%) | 39.35 ± 7.11 | −10.49 ± 2.8 a4 |
14.36 ± 4.56 a3b3 |
22.33 ± 6.12 a2b4c2e1 |
17.23 ± 4.85 a3b3 |
33.04 ± 6.61 a1b4c3d2e3 |
| Average glucose day 0 (mg/dl) | 95.6 ± 1.9 | 360.53 ± 4.72 a4 |
353.22 ± 3.85 a4 |
358.35 ± 5.11 a4 |
362.32 ± 4.54 a4 |
359.56 ± 3.87 a4 |
| Average glucose day 60 (mg/dl) | 94.81 ± 2.1 | 420.52 ± 3.85 a4g1 |
230.72 ± 3.29 a3b2g1 |
127.66 ± 5.65 b4c2e1g4 |
195.61 ± 6.11 a2b2c1g3 |
111.85 ± 4.73 b4c3d2e2g4 |
| Average insulin day 0 (ng/ml) | 0.8 | 0.23 a4 |
0.22 a4 |
0.23 a4 |
0.22 a4 |
0.23 a4 |
| Average insulin day 60 (ng/ml) | 0.84 | 0.24 a4 |
0.38 a3g1 |
0.59 a2b2c1g3 |
0.47 a2b1g2 |
0.74 b4c3d1e2g4 |
Data are presented as mean ± SEM (n = 7). aStatistically significant differences compared to control. bStatistically significant differences compared to the D group. cStatistically significant differences compared to the IT group. dStatistically significant differences compared to the IT-PRP group. eStatistically significant differences compared to the IT-PIH group. gStatistically significant differences compared to day 0 in the same group. 1p < 0.05, 2p < 0.01, 3p < 0.001, and 4p < 0.0001. Con: control rats; D: control diabetic rats; IT: islet-transplanted diabetic rats; IT-PRP: islet-transplanted diabetic rats with PRP; IT-PIH: islet-transplanted diabetic rats with PIH; IT-PRP&PIH: islet-transplanted diabetic rats with PRP&PIH.