Table 2. Number, incidence rate, and hazard ratio for cardiovascular events (myocardial infarction or stroke) Stratified by non-HDL and LDL cholesterol.
Variables | No. of patients | No. of event | Duration, person-years | Rate, events per 1,000 person-years | Non-adjusted | Model 1 | Model 2 | |
---|---|---|---|---|---|---|---|---|
Non-HDL cholesterol | ||||||||
Q1 | 959,579 | 14,927 | 8,773,254 | 1.70 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | |
Q2 | 986,931 | 19,105 | 9,038,909 | 2.11 | 1.242 (1.215–1.269) | 1.050 (1.027–1.072) | 1.074 (1.051–1.097) | |
Q3 | 965,906 | 23,255 | 8,835,420 | 2.63 | 1.547 (1.515–1.579) | 1.174 (1.150–1.199) | 1.188 (1.164–1.213) | |
Q4 | 953,950 | 31,226 | 8,684,464 | 3.60 | 2.113 (2.072–2.155) | 1.491 (1.462–1.520) | 1.456 (1.427–1.486) | |
p for trend | <0.001 | <0.001 | <0.001 | |||||
LDL cholesterol | ||||||||
Q1 | 976,661 | 19,187 | 8,904,531 | 2.15 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | |
Q2 | 975,502 | 18,776 | 8,936,121 | 2.10 | 0.974 (0.955–0.994) | 0.942 (0.923–0.961) | 1.008 (0.988–1.029) | |
Q3 | 934,272 | 21,091 | 8,553,002 | 2.47 | 1.144 (1.121–1.166) | 1.008 (0.988–1.028) | 1.091 (1.069–1.113) | |
Q4 | 979,931 | 29,459 | 8,938,393 | 3.30 | 1.528 (1.501–1.556) | 1.196 (1.174–1.218) | 1.281 (1.257–1.306) | |
p for trend | <0.001 | <0.001 | <0.001 |
Model 1: adjusted for age and sex.
Model 2: adjusted for age and sex, alcohol consumption, regular physical activity, body mass index, diabetes, hypertension, and statin use.
HDL, high-density lipoprotein; LDL, low-density lipoprotein.