Table 2.
Relationship of post-COVID-19 neuropsychiatric disorders with hospitalization and ICU admission
| Mood disorder | Anxiety disorder | Psychotic disorder | Brain fog | |
|---|---|---|---|---|
| Hospitalized versus non-hospitalized COVID-19 | ||||
| ȃHR at 6 months (95% CI) | 1.53 (1.33–1.75) | 1.49 (1.34–1.65) | 2.77 (1.99–3.85) | 2.24 (2.12–2.35) |
| ȃIncidence in hospitalized cases at 6 months, % | 4.49 (4.05–4.99) | 6.91 (6.38–7.47) | 0.89 (0.72–1.09) | 16.66 (16.14–17.17) |
| ȃIncidence in non-hospitalized cases at 6 months, % | 3.86 (3.60–4.14) | 6.81 (6.47–7.16) | 0.25 (0.19–0.33) | 4.91 (4.71–5.11) |
| ICU versus non-ICU COVID-19 | ||||
| ȃHR at 6 months (95% CI) | 2.06 (1.57–2.71) | 2.22 (1.82–2.71) | 1.77 (0.98–3.20) | 2.54 (2.32–2.74) |
| ȃIncidence in ICU cases at 6 months, % | 5.82 (4.86–6.97) | 9.79 (8.65–11.06) | 0.70 (0.46–1.06) | 27.75 (26.58–28.91) |
| Non-hospitalized COVID-19 versus non-hospitalized other RTIs | ||||
| ȃHR at 6 months (95% CI) | 1.37 (1.27–1.47) | 1.37 (1.30–1.45) | 1.49 (1.15–1.93) | N/A |
Incidence and HR in hospitalized versus non-hospitalized COVID-19 (n = 45 167 in each cohort, except n = 52 597 for brain fog); in cohorts of COVID-19 admitted or not admitted to ICU (n = 8942 in each cohort), and in non-hospitalized COVID-19 versus non-hospitalized other respiratory infections (RTIs; n = 183, 731 in each cohort). Matched cohorts used for HRs; complete cohort used for incidences. See Table 1 legend for diagnostic categories. Data from Taquet et al.,13 except for brain fog.20 These studies excluded children younger than 10 years old.