Figure 5.

Injections of patient-derived PSP-tau aggregates induce dopaminergic neuronal loss in the substantia nigra of macaques. (A) Representative images of thyroxine hydroxylase (TH) immunohistochemistry on the substantia nigra of CTL-tau (left) and PSP-tau macaques (right). (B) Stereological quantification of the number of TH+ neurons in the substantia nigra of macaques. Data are shown as mean ± SEM (horizontal lines). Each dot represents one NHP of the control (grey) and PSP-injected macaques (blue). The bootstrapped mean difference with 95% CI (error bar) is shown on the right side of this graph. Scale bars = 10 µm (inset, 20 µm).