Figure 3.

Pathological combination categories. The heterogeneous pathological combinations can be grouped into categories by expected ND including: ‘ND only’ if only the expected pathology or pathologies are present; ‘Other ND’ if the expected pathology is not present; ‘Ageing only’ for combinations also present in age-matched unimpaired cases; ‘ND + ageing’ if the expected pathology was present along with pathologies in age-matched unimpaired cases; and ‘ND + associated’ if the expected pathology was present together with other pathological combinations. We observed that ND only cases are uncommon except in the ALS and MSA groups and that ND + ageing only correlates with a minority of cases, with the implication that additional ND pathologies are frequently observed across disease.