Table 4.
Factors influencing pathological combinations
| Group | Category | Age at death | Duration | Age of onset | APOE e4 |
|---|---|---|---|---|---|
| Unimpaired | ND ageing | 1.75 (1.43–2.16) | – | – | – |
| Clinical AD | ND associated | 1.22 (1.10–1.36) | 1.56 (1.18–2.07) | – | – |
| ALS | ND associated | 1.71 (1.31–2.23) | – | 1.57 (1.22–2.03) | – |
| ND ageing | 1.78 (1.37–2.31) | – | 1.73 (1.34–2.23) | – | |
| FTD | ND associated | 1.51 (1.19–1.92) | – | 1.47 (1.15–1.88) | – |
| ND ageing | 1.60 (1.21–2.13) | – | 1.56 (1.17–2.09) | – | |
| Clinical LBD | ND associated | – | – | 1.31 (1.13–1.51) | 3.72 (1.90–7.30) |
| ND ageing | – | – | 1.27 (1.09–1.48) | 4.23 (2.10–8.52) | |
| Clinical Tau | ND associated | 1.66 (1.18–2.33) | – | 1.61 (1.14–2.27) | – |
| ND ageing | 1.62 (1.17–2.25) | – | 1.67 (1.19–2.34) | 9.36 (1.93–45.39) |
Odds ratios and 95% confidence intervals shown for P-values <0.01 after accounting for multiple comparison using Bonferroni correction (0.05 divided by number of covariates considered). Odds ratio estimates for age at death and age of onset are for 5-year increments.