Figure 1.

IPD-AR, iCJD-AR and IPD converter biofluid sample archive. This graph plots all the samples (plasma only, CSF only or matched plasma and CSF) analysed in this study, grouped by age category (<40, 40–49, 50–59 and >60) on the x-axis to obscure identities, with each minor tick mark after the start of each age category reflecting an interval of 1 year. A total of 12 years are covered per age group as the longest follow-up is over 11 years, in order to avoid overlapped timelines. The first (or only) sample from each individual is collapsed to the start of each age category to preserve anonymity. Samples from the same individual are joined by a horizontal line if more than one sample was collected; thick black horizontal lines denote onset of clinical conversion. Converters are grouped together in the upper shaded part of the graph. For converters where only one presymptomatic sample exists without any follow-up samples, the subsequent data-point (unfilled inverted triangle marker) joined by line indicates time of death. IPD mutations with fewer than five at-risk individuals were grouped as ‘Other’ to avoid self-identification.