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Converter trajectories for plasma GFAP and NfL and CSF NfL. Plasma GFAP (A) and NfL (B) trajectories are grouped into P102L (slow IPD) and E200K + D178N-FFI (fast IPDs) and OPRIs (slow IPDs; includes 5- and 6-OPRI). CSF converter data-points for NfL are shown in C. The horizontal dotted line indicates the 90th percentile of the respective biomarker value in the normal control cohort.
