Table 4.
Ciprofloxacin MIC values reported by published studiesa
| First author and year of publication | Total isolates R (%)/total isolates evaluated | MIC50 (mg/L) | MIC90 (mg/L) | Range (mg/L) | Method used for MIC determination | Resistance breakpoints used (MIC breakpoint for R) |
|---|---|---|---|---|---|---|
| Casco 2011 (Argentina)45 | 47 (25.8)/181 | 0.016 | 16 | 0.001 to 32 | agar dilution | CLSI (NR) |
| Zotta 2014 (Argentina)70 | 14 (29.5)/48 | — | — | 0.004 to 16 | agar dilution | CLSI (NR) |
| Galarza 2014 (Argentina)52 | 198 (49)/404 | 0.016 | 16 | — | agar dilution | CLSI (NR) |
| Vacchino 2017 (Argentina)67 | NR/40 | 1 | 4 | — | agar dilution | CLSI (NR) |
| Martins 2019 (Brazil)57 | 20 (15.3)/124 | 0.002 | >2 | ≤0.00025 to >2 | agar dilution | EUCAST (R > 0.06 mg/L) |
| Costa-Lourenço 2018 (Brazil)47 | 75 (64.7)/116 | 2 | 16 | 0.002 to 32 | agar dilution | CLSI (NR) |
| Costa 2013 (Brazil)46 | 43 (21.4)/201 | 0.002 | 4 | 0.002 to >32 | DD/Etest | CLSI (R ≥ 1 mg/L) |
| Bazzo 2018 (Brazil)44 | 306 (55.6)/550 | 0.016 | 8 | 0.001 to 32 | agar dilution | CLSI (R ≥ 1 mg/L) |
All MIC data expressed in mg/L; however, some of the original studies used units of µg/mL. CLSI, Clinical and Laboratory Standards Institute; DD, disk diffusion; EUCAST, European Committee on Antimicrobial Susceptibility Testing; MIC, minimum inhibitory concentration; NR, not reported; R, resistant. MIC50: MIC of the antibiotic that inhibits the growth of 50% of the strains. MIC90: MIC of the antibiotic that inhibits the growth of 90% of the strains.