Table 7.

Spectinomycin MIC values reported by published studies^a

First author and year of publication	Total isolates R (%)/total isolates evaluated	MIC50 (mg/L)	MIC90 (mg/L)	Range (mg/L)	Method used for MIC determination	Resistance breakpoints used (MIC breakpoint for R)
Casco 2011 (Argentina)45	0 (0)/181	16	64	0.5–64	agar dilution	CLSI (NR)
Zotta 2014 (Argentina)70	0 (0)/48	—	—	16–32	agar dilution	CLSI (NR)
Costa 2013 (Brazil)46	12 (6)/201	4–24	—	—	DD/Etest	CLSI (NR)

All MIC data expressed in mg/L; however, some of the original studies used units of µg/mL. CLSI, Clinical and Laboratory Standards Institute; DD, disk diffusion; MIC, minimum inhibitory concentration; NR, not reported; R, resistant. MIC₅₀: MIC of the antibiotic that inhibits the growth of 50% of the strains. MIC₉₀: MIC of the antibiotic that inhibits the growth of 90% of the strains.