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. 2023 Apr 24;24(6):941–954. doi: 10.1038/s41590-023-01499-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Scaled and centered levels of neutralizing (NAb) and spike-specific (anti-S-RBD IgG) antibodies as well as SARS-CoV-2 spike peptide-induced T cell IFNγ production for each vaccine combination at T3 (n = 347). b, Scaled and centered values per column of the top humoral and cellular immune features for each immune signature, displayed in a heatmap with k-means clustering applied to the rows and columns (n = 347). c, Anti-S-RBD IgG levels, anti-S-RBD IgA levels, NAb titers and SARS-CoV-2 spike peptide-induced IFNγ production from all participants grouped by immune signature (n = 347). Large black dots depict the median of the group, and the vertical line spans the IQR. P values indicate differences between the respective group and the overall mean of all participants and were calculated using the Mann–Whitney–Wilcoxon test and the Benjamini–Hochberg method to control for multiple hypothesis testing. Only significant P values (P < 0.05) are displayed. d, Principal component analysis of the top humoral and cellular immune features for each immune signature at T3 (n = 347).

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