Table 3.
Incidence proportions of ADRs of Grade ≥ 3 by age, liver function, and renal function
| Variable | Category | Total | Patients with ADRs of Grade ≥ 3 | p-valuea | |
|---|---|---|---|---|---|
| n | (%) | ||||
| All | 703 | 299 | (42.5) | ||
| Age (years) | < 65 | 117 | 43 | (36.8) | 0.183 |
| ≥ 65 | 586 | 256 | (43.7) | ||
| Child-Pugh class | A | 624 | 260 | (41.7) | 0.140 |
| B or C | 75 | 38 | (50.7) | ||
| mALBI grade | 1 or 2a | 415 | 159 | (38.3) | 0.003* |
| 2b or 3 | 276 | 137 | (49.6) | ||
| 1 | 216 | 77 | (35.6) | 0.010* | |
| 2a, 2b, or 3 | 475 | 219 | (46.1) | ||
| eGFR (mL/min/1.73 m2) | ≥ 45 | 615 | 263 | (42.8) | 1.000 |
| < 45 | 72 | 31 | (43.1) | ||
ADR adverse drug reaction, eGFR estimated glomerular filtration rate,
mALBI grade, modified albumin-bilirubin grade
aFisher’s exact test
*p < 0.05