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. 2023 May 31;9:82. doi: 10.1038/s41531-023-00527-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAPs of control and different Braak stages PD brain samples. b Cluster composition of myeloid, oligodendrocyte progenitor cells (OPC), endothelial cells (End), neurons (Neu), astrocytes (Ast), oligodendrocytes (Oli), and microglia (Mic) from snRNA sequencing. c, d Single-cell RNA sequencing of GSE184950 visualizing UMAP cell clusters, PLOD3 and LRRN3 expression. The cellular subpopulation expression of the PLOD3 and LRRN3 has significant distributional variability. The expression of PLOD3 was more enriched in astrocytes, microglia and oligodendrocytes cell clusters, whereas LRRN3 was more enriched in neurons and oligodendrocyte progenitor cells clusters. e–h The combined GSEA curves using GO-BP and KEGG analysis visualize the functions of PLOD3 and LRRN3.