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. 2023 May 31;13:8872. doi: 10.1038/s41598-023-35978-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RSL3 promoted ferroptosis-associated characteristics. Cells were treated with RSL3, with or without ferrostatin-1 for 24 h (A, B, D). (A) Intracellular LIP expression level measured by the fluorescence intensity of FerroOrange. (B) Lipid peroxidation detected by BODIPY 581/591 C11 staining (scale bar: 20 µm). (C) Cellular ROS level determined by DCFA/H2DCFDA-cellular ROS assay kit after treatment with RSL3 for 6 h. (D) GSH/GSSH ratio determined by an EZ-Glutathione assay kit. Results are shown as the mean ± SD of at least triplicate experiments. *p < 0.05, **p < 0.01, ***p < 0.001 compared with control.