Table 1.
KEGG analysis of downregulated miRNA predicted targets.
| miRNA | Function of Predicted Target |
|---|---|
| aae-mir-1175 | MAPK Signaling Pathway |
| Longevity Regulating Pathway | |
| Phosatidylinositol Signaling Pathway | |
| NOD-like Receptor Signaling Pathway | |
| Wnt Signaling Pathway | |
| Notch Signaling Pathway | |
| TGFβ Signaling Pathway | |
| FoxO Signaling Pathway | |
| Toll and Imd Signaling Pathway | |
| aae-mir-2945 | Phosatidylinositol Signaling Pathway |
| MAPK Signaling Pathway | |
| Wnt Signaling Pathway | |
| Toll and Imd Signaling Pathway | |
| Insulin Signaling Pathway | |
| Neurotrophin Signaling Pathway | |
| TGFβ Signaling Pathway | |
| FoxO Signaling Pathway | |
| Phosatidylinositol Signaling Pathway | |
| mTOR Signaling Pathway | |
| Longevity Regulating Pathway | |
| Ras Signaling Pathway | |
| bmo-mir-6497 | Toll and Imd Signaling Pathway |
| MAPK Signaling Pathway | |
| Notch Signaling Pathway | |
| Longevity Regulating Pathway | |
| mTOR Signaling Pathway | |
| Wnt Signaling Pathway | |
| FoxO Signaling Pathway | |
| p53 Signaling Pathway | |
| Hedgehog Signaling Pathway | |
| Rap1 Signaling Pathway | |
| Insulin Signaling Pathway | |
| Neurotrophin Signaling Pathway | |
| PC-5p-30141_33 | Hedgehog Signaling Pathway |
| MAPK Signaling Pathway | |
| TGFβ Signaling Pathway | |
| mTOR Signaling Pathway |
KEGG analysis of genes predicted to be targets of six Aag2 miRNAs significantly downregulated by parasite EV treatment. This analysis revealed an enrichment of immune signaling pathways, including the immune signaling pathways Toll/IMD, MAPK, TGFβ and insulin signaling.