Table 3.
Hazard ratios (95% confidence intervals) for acute myocardial infarction (AMI) according to the joint association of self-reported insomnia symptoms and sleep duration in UK Biobank (UKBB) and HUNT2.
| No insomnia symptoms | Insomnia symptoms | ||||||
|---|---|---|---|---|---|---|---|
| Sleep duration | Sleep duration | ||||||
| Short | Normal | Long | Short | Normal | Long | ||
| UK Biobank (n = 302 456) |
AMI events/ Person-years |
900/ 427 642 |
3 395/ 1 951 096 |
489/ 204 765 |
894/ 416 379 |
970/ 494 794 |
185/ 53 695 |
| Model 1 |
1.16 (1.08, 1.25) |
Ref. |
1.22 (1.11, 1.34) |
1.32 (1.23, 1.42) |
1.12 (1.05, 1.21) |
1.72 (1.49, 2.00) |
|
| Model 2 |
1.07 (0.99, 1.15) |
Ref. |
1.09 (0.99, 1.20) |
1.16 (1.07, 1.25) |
1.07 (0.99, 1.15) |
1.40 (1.21, 1.63) |
|
| Model 3 |
1.08 (1.00, 1.16) |
Ref. |
1.05 (0.96, 1.16) |
1.13 (1.04, 1.21) |
1.05 (0.98, 1.13) |
1.32 (1.14, 1.54) |
|
| HUNT2 (n = 31 091) |
AMI events/ Person-years |
106/ 32 967 |
1 420/ 420 985 |
594/ 123 267 |
45/ 8 339 |
248/ 49 360 |
127/ 18 692 |
| Model 1 |
1.10 (0.90, 1.34) |
Ref. |
1.06 (0.96, 1.17) |
1.38 (1.03, 1.86) |
1.17 (1.03, 1.34) |
1.19 (0.99, 1.43) |
|
| Model 2 |
1.02 (0.84, 1.24) |
Ref. |
0.97 (0.88, 1.07) |
1.17 (0.87, 1.58) |
1.09 (0.95, 1.25) |
1.02 (0.85, 1.23) |
|
| Model 3 |
1.08 (0.89, 1.32) |
Ref. |
0.94 (0.85, 1.04) |
1.18 (0.87, 1.60) |
1.08 (0.94, 1.25) |
0.97 (0.80, 1.19) |
|
Model 1, adjusted for age and gender
Model 2, adjusted for covariates in Model 1, along with marital status, alcohol intake frequency, smoking status, body mass index, physical activity, education, Townsend deprivation index (for UKBB), ethnicity (for UKBB), shift work, and employment status
Model 3, adjusted for covariates in Model 2, along with systolic blood pressure, serum cholesterol level, blood glucose level, time since last meal, use of sleep medication(s), depression, and anxiety