Table 4.
Hazard ratios (95% confidence intervals) for acute myocardial infarction (AMI) according to the joint association of self-reported insomnia symptoms and chronotype in UK Biobank
| No insomnia symptoms | Insomnia symptoms | ||||
|---|---|---|---|---|---|
| Chronotype | Chronotype | ||||
| Morning | Evening | Morning | Evening | ||
| UK Biobank (n = 302 456) |
AMI events/ Person-years |
2 953/ 1 625 404 |
1 831/ 958 099 |
1 253/ 604 533 |
796/ 360 335 |
| Model 1 | Ref. |
1.12 (1.06, 1.19) |
1.17 (1.10, 1.25) |
1.36 (1.26, 1.47) |
|
| Model 2 | Ref. |
1.08 (1.02, 1.15) |
1.11 (1.04, 1.18) |
1.19 (1.10, 1.29) |
|
| Model 3 | Ref. |
1.07 (1.01, 1.14) |
1.09 (1.02, 1.17) |
1.14 (1.06, 1.24) |
|
Model 1, adjusted for age and gender
Model 2, adjusted for covariates in Model 1, along with marital status, alcohol intake frequency, smoking status, body mass index, physical activity, education, Townsend deprivation index, ethnicity, shift work, and employment status
Model 3, adjusted for covariates in Model 2, along with systolic blood pressure, serum cholesterol level, blood glucose level, time since last meal, use of sleep medication(s), depression, and anxiety