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. 2023 May 4;163(1):47–59. doi: 10.1007/s11060-023-04287-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A, Volcano plots showing the results of differential expression analyses by comparing the three groups of previously identified samples in pairs. The cut-off for log2FC and for adjusted P value are > 2 and 10e-6. Only the names of the genes present in the previous heatmap or those more up/down-regulated in single pairwise comparisons are reported. B, Pathways differentiating the three GSC different clusters identified by gene expression enrichment:Venn diagrams showing the number of specific and common genes in the comparison between each cluster against the other two; the latter were considered as putative “marker genes” for each cluster and gene set enrichment was tested against the Panther (2016) metabolic and cell signaling pathway database. C, The bar chart visualizes the top 10 enriched terms and their p-values. Bars are colored based on their p-values, while an asterisk next to a p-value indicates the term also has a significant adjusted p-value (< 0.05). The three different clusters were indicated (I, II and III)

Fig. 5 — A, Volcano plots showing the results of differential expression analyses by comparing the three groups of previously identified samples in pairs. The cut-off for log2FC and for adjusted P value are > 2 and 10e-6. Only the names of the genes present in the previous heatmap or those more up/down-regulated in single pairwise comparisons are reported. B, Pathways differentiating the three GSC different clusters identified by gene expression enrichment:Venn diagrams showing the number of specific and common genes in the comparison between each cluster against the other two; the latter were considered as putative “marker genes” for each cluster and gene set enrichment was tested against the Panther (2016) metabolic and cell signaling pathway database. C, The bar chart visualizes the top 10 enriched terms and their p-values. Bars are colored based on their p-values, while an asterisk next to a p-value indicates the term also has a significant adjusted p-value (< 0.05). The three different clusters were indicated (I, II and III)