Table 1.
CarD binding is associated with both activated and repressed transcription start sites (TSSs)
| Differentially Expressed |
Not Significant | TOTAL | |||
|---|---|---|---|---|---|
| TSS category | Activated | Repressed | Uncategorized | ||
| Overlapping with CarD binding site | 62 (53.0%) | 103 (67.3%) | 120 (54.0%) | 1089 (44.9%) | 1374 (47.1%) |
| Total # TSSs | 117 | 153 | 222 | 2425 | 2917 |
‘Differentially Expressed’ TSSs are those TSSs associated with genes that were significantly differentially expressed (padj<0.05) in both CarDR25E and CarDI27W relative to CarDWT. A differentially expressed gene was categorized as: ‘Activated’ if it was down-regulated in CarDR25E and up-regulated in CarDI27W, ‘Repressed’ if it was up-regulated in CarDR25E and down-regulated in CarDI27W, or ‘Uncategorized’ if it was differentially expressed in the same direction in both mutant strains. TSSs associated with genes that were not significantly differentially expressed in both mutant strains were categorized as ‘Not Significant’. The percent of total TSSs in a given category that overlapped with a CarD binding site is shown in the parentheses.